We found that Ang-2 (AUROC 0.75, best cutoff > 2800 pg-mL), RAGE (AUROC 0.69, best cutoff < 208 pg/mL), VCAM-1 (AUROC 0.74, best cutoff > 1312 ng/mL) and ICAM-1 (AUROC 0.63, best cutoff > 1092 ng/mL) were able to discriminate between COVID-19 and classical ARDS. The gene discussed is ANGPT2; the disease is COVID-19.