It was illustrated by apoptosis assay that miR-378a-5p overexpression enhanced the CRC cell numbers at the G2-M phase and cell apoptosis, whereas CDK1 upregulation resulted in the opposite trend; the upregulation of miR-378a-5p and CDK1 together induced a trend similar to the control group (Fig. 6c, d). The gene discussed is CDK1; the disease is colorectal carcinoma.