To better investigate the mechanism underlying the impact of miR-378a-5p on inhibiting CRC cell proliferation and migration, TargetScan was used in combination with RNAhybrid for predicting miR-378a-5p target genes and revealing whether miR-378a-5p binds to CDK1 mRNA (Fig. 4a). The gene discussed is CDK1; the disease is colorectal carcinoma.