HIF1A and pancreatic neoplasm: We found that after the treatment of pancreatic cancer BxPC-3 cells with 2-DG in different concentrations, with the concentration increasing, the protein level of P-STAT3 decreased significantly (Fig. 8a, c), and qPCR showed that STAT3 and its downstream target genes, VEGF and HIF1A were also decreased (Fig. 8i).