We found that after the treatment of pancreatic cancer BxPC-3 cells with 2-DG in different concentrations, with the concentration increasing, the protein level of P-STAT3 decreased significantly (Fig. 8a, c), and qPCR showed that STAT3 and its downstream target genes, VEGF and HIF1A were also decreased (Fig. 8i). Here, HIF1A is linked to familial pancreatic carcinoma.