The accumulation of unphosphorylated β-catenin in the cytosol migrates to the nucleus, interacting with T cell-specific factor (TCF)/lymphoid enhancer-binding factor (LEF) and co-activators to turn on the Wnt target genes such as c-Myc, cyclin D1 and Cdkn1a, thereby enabling tumor cells to gain growth and metastatic dynamics. The gene discussed is HNF4A; the disease is neoplasm.