((Diabetes Mellitus, Type 2):ti, ab, kw OR (Type 2 Diabetes Mellitus):ti, ab, kw OR (NIDDM):ti, ab, kw OR (Type 2 Diabetes):ti, ab, kw) AND ((glucokinase activator):ti, ab, kw OR (Dorzagliatin):ti, ab, kw OR (HMS5552):ti, ab, kw OR (Piragliatin):ti, ab, kw OR (RO4389620):ti, ab, kw OR (AMG 151):ti, ab, kw OR (ARRY-403):ti, ab, kw OR (AZD1656):ti, ab, kw OR (AZD6370):ti, ab, kw OR (TMG-123):ti, ab, kw OR (MK-0941):ti, ab, kw OR (TTP-399):ti, ab, kw OR ("SY004):ti, ab, kw) OR (GKM001):ti, ab, kw. The gene discussed is GCK; the disease is type 2 diabetes mellitus.