(“Diabetes Mellitus, Type 2”[MeSH Terms] OR “Type 2 Diabetes Mellitus” OR “NIDDM” OR “Type 2 Diabetes”) AND (“glucokinase activator”[MeSH Terms] OR “Dorzagliatin” OR “HMS5552” OR “Piragliatin” OR “RO4389620” OR “AMG 151” OR “ARRY-403” OR “AZD1656” OR “AZD6370” OR “TMG-123” OR “MK-0941” OR “TTP-399” OR “SY004” OR “GKM001”) AND clinical trial[ptyp]. This evidence concerns the gene GCK and diabetes mellitus.