(“Diabetes Mellitus, Type 2”/exp OR “Type 2 Diabetes Mellitus” OR “NIDDM” OR “Type 2 Diabetes”) AND (“glucokinase activator”/exp OR “ Dorzagliatin”:ti, ab, kw OR “HMS5552”:ti, ab, kw OR“Piragliatin”:ti, ab, kw OR “RO4389620”:ti, ab, kw OR” AMG 151 “ti, ab, kw OR “ARRY-403”:ti, ab, kw OR “AZD1656”:ti, ab, kw OR “AZD6370”:ti, ab, kw OR “TMG-123”:ti, ab, kw OR “MK-0941”:ti, ab, kw OR “TTP-399”:ti, ab, kw OR “SY004”:ti, ab, kw OR “GKM001”:ti, ab, kw) AND ’randomized controlled trial’/de. The gene discussed is GCK; the disease is type 2 diabetes mellitus.