As one of the common single nucleotide polymorphisms (SNPs) in ER-β gene, the G/A exchange at nucleotide 1730 in the 3’ untranslated region (3’-UTR) of exon 8 (+1730 G/A, rs4986938) is investigated substantially in various gynecological diseases, especially in RPL.[7,12–14] However, it remains unclear about the association between ER-β gene +1730G/A polymorphisms and RPL risk. The gene discussed is ESR2; the disease is female reproductive system disorder.