CDT1 and Ear-patella-short stature syndrome: Chromatin licensing and DNA replication factor 1 (CDT1) (OMIM: 605525), located at 16q24.3, is required for DNA replication at multiple stages of development and mitosis.[41] CDT1 has been indicated to be associated with Meier-Gorlin syndrome 4.[42] Patients with this syndrome usually have distinctive facial features, full lips, low-set/rotated ears, micrognathia, short stature, patellar aplasia/hypoplasia, narrow nose with a high nasal bridge and abnormalities in sexual development.