CXCL8 and gastric cancer: Of the 25 significant signaling pathways, 5 pathways (sirtuin signaling, interferon signaling, IL-8 signaling, neuroinflammation signaling, and inflammasome) with z-score > 0 were predicted to be activated in GC, whereas 20 pathways (z-score < 0) were predicted to be inhibited (Figure 4A).