TF and viral infectious disease: As expected, H3K27ac peaks linked to these genes through HiChIP interactions in HaCaT were enriched for TF motifs that are known to be involved in the response to IFN-γ stimulation and/or viral infection (Ramezani et al., 2018; Schroder et al., 2004) and contained similar motifs to those identified in peaks that had different H3K27ac signal in the stimulated condition (Supplementary Figure S5f).