Fifty-seven percent of the patients with a positive test result harbored PVs in high-penetrance BC genes (41.3% in BRCA1/2, 17.4% in TP53, and 2.2% in PALB2), 15.2% in moderate penetrance BC genes (2.2% in ATM and 13% in CHEK2), and 23.9% in genes considered to be associated with a BC potential increased risk or an unknown risk. The gene discussed is TP53; the disease is breast cancer.