BRCA1 and breast carcinoma: We next determined the power of the competing RVAS tests to identify the 8 breast cancer risk genes (BRCA1-Missense, BRCA1-LoF, BRCA2-Missense, BRCA2-LoF, PALB2, BRIP1, CHEK2 and BARD1) at the three TIER levels 5%, 0.1% and 0.01% and at three levels of VE of 2%, 1% and 0.5% (1000GP: Fig 2, Iberian: S6 Fig).