The patients who develop limb ischemia had significantly higher INR (1.9 (1.4–3.2) vs 1.4 (1.1–3.6), p = 0.004) and AT III level (69 (27–88) vs 55.5 (42–73), p = 0.002) at time of ECMO initiation compared to those who did not develop ischemia. The gene discussed is SERPINC1; the disease is limb ischemia.