As anticipated, ESCC cell lines with UBQLN4‐OV presented a reduction in 53BP1 (Fig. 6A–F) and γ‐H2AX foci formation (Fig. 6G–L) compared to control EV cell lines in both cisplatin‐treated and nontreated conditions. This evidence concerns the gene UBQLN4 and esophageal squamous cell carcinoma.