As anticipated, ESCC cell lines with UBQLN4‐OV presented a reduction in 53BP1 (Fig. 6A–F) and γ‐H2AX foci formation (Fig. 6G–L) compared to control EV cell lines in both cisplatin‐treated and nontreated conditions. The gene discussed is H2AX; the disease is esophageal squamous cell carcinoma.