Thus, we demonstrate here that EWI‐2 is highly expressed in exosomes and that the nuclear envelope, which governs the packaging of miRNA into exosomes, affects the cell membrane growth factor epidermal growth factor receptor‐mitogen‐activated protein kinase‐extracellular‐signal‐regulated kinase (EGFR‐MAPK‐ERK) signaling pathway and further leads to inhibited prostate cancer cell metastasis. The gene discussed is EGFR; the disease is prostate cancer.