In addition to the EGFR signaling change, there were also changes in several cancer‐associated proteins, such as vimentin; the marker of epithelial‐to‐mesenchymal transition (EMT) was upregulated in PC3 knockdown cells and the EMT regulator β‐catenin was upregulated upon EWI‐2 knockdown. The gene discussed is EGFR; the disease is cancer.