It will next be important to develop an understanding of how SARM protein expression is regulated in RA, as this may have relevance to RA comorbidities and other diseases where NLRP3 activation and excess IL-1β are associated with disease pathology, such as cardiovascular disease, type 2 diabetes and Alzheimer’s disease [39]. Here, SARM1 is linked to early-onset autosomal dominant Alzheimer disease.