CASP1 and rheumatoid arthritis: To explore this enhancement of IL-1β secretion from RA monocytes, the gene expression of inflammasome components NLRP3 (gene name NLRP3), pro-caspase-1 (gene name CASP1), apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC; gene name PYCARD) and the NLRP3 inhibitor SARM (gene name SARM1) were measured.