C-X-C Motif Chemokine Ligand 1(CXCL1)/CXCR2 biological axis plays an important role in the modulation of theadhesion and aggregation of macrophages in the aortic wall, and mediates theinflammatory response in vascular diseases such as hypertension andatherosclerosis10,11. Here, CXCR2 is linked to hypertensive disorder.