In thispaper, it was revealed that in ApoE-/- mice, Ang II decreased theexpression of α-SMA and increased the expression of OPN and TGF-β1, while inhibitionof CXCR2 improved the expression of α-SMA and inhibited the expression of TGF-β1 andOPN in Ang II-treated ApoE-/- mice, indicating that inhibition of CXCR2might prevent AAA by inhibiting VSMCs phenotypic switching. Here, SPP1 is linked to triple-A syndrome.