This regulatory pathway may also be impaired in lamin-linked diseases, such as the premature aging disease Hutchinson Gilford Progeria Syndrome (HGPS), where LAP2α expression is lost, leading to premature senescence, while re-expression of LAP2α in HGPS cells rescues cell proliferation (Vidak et al., 2015). The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.