In the present study, we investigated the presence of p62 proteotoxic aggregates in genetic cardiomyopathies caused by pathogenic mutations in different cardiomyopathy‐related genes (DES, CRYAB, PLN, PKP2, DSP, LMNA, MYBPC3, MYH7, TNNI3 and TNNT2). This evidence concerns the gene DES and cardiomyopathy.