NLRP3, caspase 1 and IL‐1β were also tested at the protein level, and it showed a slight increase in the CIS + LPZ 12.5 group and a significant increase in the CIS + LPZ 25 group compared to that in the CIS group (Figure 5D,E and Figure S3). The gene discussed is IL1B; the disease is in situ carcinoma.