STAT3 and neoplasm: Wen and colleagues uncovered that within several tumour models, the TRAPs could skew macrophages into M2‐phenotype with higher levels of PD‐L1 and IL‐10 via Toll‐like receptor 4 (TLR4)‐MyD88‐p38‐STAT3 pathway, therefore resulting in suppression of CTL function and reduced IFN‐γ secretion.24