Methods using standard antibodies for CTC capture and identification (i.e., epithelial cell adhesion molecule (EpCAM) and cytokeratin (CK)), which can be downregulated in ccRCC, only identified CTCs in 16‐25% of patients and with an average of 1 CTC per 7.5mL of blood [13, 14, 15, 16, 17, 18]. Here, EPCAM is linked to nonpapillary renal cell carcinoma.