MIC-1 levels in the CHC patients with type 1b were correlated to liver cell injury, liver fibrosis index, and viral load, and the changes in the MIC-1 levels indicated the therapeutic effect of PR regimen, while the polymorphism of rs1059369 and rs1059519 did not affect the level of MIC-1 in CHC patients. The gene discussed is GDF15; the disease is cryohydrocytosis.