Mutations in TP53 gene are associated with variety of malignancies including Li-Fraumeni syndrome (Petitjean et al. 2007), colon cancer (Munro et al. 2005), lung cancer (Peifer et al. 2012), esophageal cancer (Makino et al. 2010), ovarian cancer (Ahmed et al. 2010), breast cancer (Olivier et al. 2006) and are attributed to aggressiveness of the disease (Schmitt et al. 2002). The gene discussed is TP53; the disease is breast carcinoma.