DNMT1 and neoplasm: However, Intabli et al (2019) showed that treatment of triple negative breast cancer cell lines MDA-MB-231 and Hs578T with cortisol decreased the expression of DNMT1 leading to hypomethylation of promoter regions of key tumor suppressor genes including DAPK1, AKT1, ABL1, CDKN1A and MGMT (Intabli et al. 2019).