Tsai et al. (2002) demonstrated that introduction of EBV product LMP1 (latent membrane protein 1) oncoprotein in to MCF-7 breast cancer cell line activated DNMT1, DNMT3A and DNMT3B resulted in the silencing of CDH1 (Tsai et al. 2002). The gene discussed is DNMT3A; the disease is breast carcinoma.