DUSP1 and breast cancer: Glucocorticoids exerts anti-proliferative and anti-apoptotic activity on breast cancer epithelial cells, at least in part, via modulating transcriptional regulation of genes encoding cell survival pathways such as SGK1 and MKP1/DUSP1 (Mikosz et al. 2001; Wu et al. 2004; Melhem et al. 2009).