BRCA1 and breast cancer: Jin et al. (2010) reported that UHRF1 is overexpressed in BRCA1 hyper methylated breast tumor tissues and overexpression of UHRF1 in breast cancer cell lines led to deacetylation of H3/H4 followed by DNMT1 recruitment on to BRCA1 promoter and hypermethylation (Jin et al. 2010).