Our recent studies in clinically characterized human breast tumor tissues, we demonstrated IL-6 induced proteasomal degradation of DNMT1 which led to promoter DNA hypomethylation of VEGFR2 promoter and subsequently to disorganized sprout formation in endothelial cells isolated from malignant part of breast tissue (Hegde et al. 2020). The gene discussed is DNMT1; the disease is breast neoplasm.