Furthermore, Xiong et al. (2005) demonstrated that endometrioid cancers frequently showing hypermethylation in the promoters of tumor suppressor genes over expressed DNMT1 and DNMT3B and serous endometrial cancers developed due to P53 mutation, loss of heterozygosity and aneuploidy showed substantial reduction in DNMT1 and DNMT3B levels than controls (Xiong et al. 2005). The gene discussed is DNMT3B; the disease is neoplasm.