Authors showed that treatment of breast cancer cell lines with 5-aza-deoxycytidine prevented the promoter CpG methylation of E-cadherin and treatment of cells with ERK inhibitor reduced the expression of DNMT1, Slug and snail indicating the synergistic role of histone methylation, deacetylation and methylation-mediated chromatin remodeling during breast tumorigenesis (Pradhan et al. 2019). This evidence concerns the gene SNAI2 and breast carcinoma.