In addition, Liu et al (2018) showed that trimethylation of H3K27 by EZH2 leading to the formation of H3K27me3-EZH2-DNMT1 complex formation and hypermethylation of Kibra (wwc1) gene CpG island resulted in epithelial mesenchymal transition of triple breast cancer cell lines (Liu et al. 2018). The gene discussed is DNMT1; the disease is breast cancer.