DNMT1 and breast neoplasm: Furthermore, Duvall-Noelle et al. (2016) showed that LASP-1 (LIM and SH3 protein 1) interaction with UHRF1-DNMT1-Snail1 complex is associated with alteration in epigenetic modifications leading to breast tumor cell migration, local invasion and metastasis (Duvall-Noelle et al. 2016).