Using cell lines and extensive bioinformatic analysis, Esteve et al. (2016) showed that 14-3-3 is a reader protein of DNMT1 S143 and interact with phosphorylated DNMT1 inducing aberrant DNA methylation and alter gene expression leading to tumor progression and cell invasion in breast cancer (Estève et al. 2016). The gene discussed is DNMT1; the disease is breast cancer.