EZH2 and breast cancer: In addition, Liu et al (2018) showed that trimethylation of H3K27 by EZH2 leading to the formation of H3K27me3-EZH2-DNMT1 complex formation and hypermethylation of Kibra (wwc1) gene CpG island resulted in epithelial mesenchymal transition of triple breast cancer cell lines (Liu et al. 2018).