Indeed, CXCR4 is among the upregulated genes of both high- and low-viral-load COVID-19 [30], while EPHRIN genes, ERG, EGR3, and NOTCH3 encoding for important regulators of sprouting angiogenesis, are downregulated in COVID-19 (own unpublished data and [21]). This evidence concerns the gene NOTCH3 and COVID-19.