ANGPT2 and acute respiratory distress syndrome: Ang-2 (Ang-2) serves as an antagonist of Ang-1 and inhibits its antiinflammatory, anticoagulatory, and antiapoptotic signaling [78]; importantly, Ang-2 is directly linked to ALI and increases pulmonary vascular permeability [79], and its levels correlate with prognosis in COVID-19 [80].