NF2 and NF2-related schwannomatosis: The incidence of NF2 is estimated to be around one in 33,000 live births based on a study by Evans et al.3 In 1992, the diagnostic prevalence of NF2 was estimated to be about one in 210,000 individuals, but improvements in diagnostic techniques and imaging modalities have led to an apparent increase to one in 100,000 people by 2005.3,4 Unfortunately, epidemiological research on NF2 is complicated by de novo mutation rates and rarity of the disease.