M1 macrophages are activated by microbial agents and/or Th1 cytokines, such as interferon gamma (IFN-γ), can increase the phagocytic capacity along with the expression of costimulatory molecules (such as CD86) and secrete proinflammatory cytokines (TNF-α, IL-6, and IL-12), and play essential roles in clearing bacterial, viral, or fungal infections and causing tissue damage [13]. Here, IFNG is linked to fungal infectious disease.