Specifically, downregulated tumor associate macrophage (CD11b+F4/80+Ly6C−Ly6G−MHCII+), upregulated neutrophils (CD11b+F4/80+/-Ly6C+MHCII+), and upregulated CD8 T cells (CD3+CD8+) could be observed in the p75NTR/proBDNF overexpression group. The gene discussed is BDNF; the disease is neoplasm.