CENPC and autoimmune disease: We found that the CENP-C antibody produced by the autoimmune method in mice could penetrate oocytes and cause oocyte maturation and spindle defects and penetrate chromosomes that were detached from the metaphase plate and scattered in the cytoplasm in metaphase, which may be the main mechanism of adverse reproductive outcomes for anticentromere antibody-positive women who have no clinical symptoms of any autoimmune diseases.