KLF11 and diabetes mellitus: Furthermore, Neve et al. identified two rare KLF11 variants (Ala347Ser and Thr220Met) in families with early onset type 2 diabetes, which were shown to significantly impair the transcriptional activity of KLF11. Furthermore, they discovered a frequent polymorphic Gln62Arg variant that was significantly associated with type 2 diabetes mellitus in North European populations [2].