In agreement with previously reported results, oral treatment with L. lactis MG1363 FnBPA+ (pValac::dts::IL-4) and L. lactis MG1363 FnBPA+ (pValac::IL-10) showed promising results indicating increased levels of IL-4 in serum and pancreas of NOD mice, further corroborating the beneficial role of the strategy tested here for the prevention of T1D. Here, IL4 is linked to type 1 diabetes mellitus.