In conclusion, the results of our study demonstrate that the combined administration of L. lactis MG1363 FnBPA+ strains carrying the eukaryotic expression plasmids pValac::dts::IL-4 and pValac::IL-10 attenuated the initial progression of insulitis in the STZ-induced model by increasing levels of IL-2 in pancreatic tissue and protected NOD mice against T1D in the observational period. The gene discussed is IL4; the disease is type 1 diabetes mellitus.