In the present study, we examined the effect of oral administration of L. lactis MG1363 FnBPA+ (pValac::dts::IL-4) and L. lactis MG1363 FnBPA+ (pValac::IL-10) in the two most extensively used animal models of T1D, the STZ-induced model, and NOD mice. The gene discussed is IL10; the disease is type 1 diabetes mellitus.