Univariate analysis indicated that the factors significantly associated with survival were tumor size (P = 0.037), lymph node metastasis (P = 0.002), lymphovascular invasion (P = 0.048), distant metastasis (P = 0.002), depth of invasion (P < 0.001), TNM stage (P < 0.001), and VCAN expression (P = 0.003) (Table 2). The gene discussed is VCAN; the disease is neoplasm.