VCAN and bladder transitional cell carcinoma: In order to investigate the role of VCAN in human BLCA progression, we first performed bioinformatics analysis with published datasets to detect the VCAN mRNA levels in BLCA by the UALCAN database, and the results reveal that the VCAN mRNA level was significantly higher in patients with BLCA, and a high mRNA level of VCAN was associated with stages, histological subtypes, molecular subtypes, and node metastasis (Figure 1).