CD3E and neoplasm: Our results showed that the expression of CDCA3 was significantly associated with gene markers of all subsets of T cells (CD3D: partial cor = 0.435, p = 2.13E − 17; CD3E: partial cor = 0.344, p = 4.82E − 1; and CD2: partial cor = 0.347, p < 0.0001) adjusted by tumor purity (Figure 5(a) and Table 3), which indicated that CDCA3 was related to cytokine secretion.