GZMB and neoplasm: The expression of CDCA3 was also associated with the gene markers of exhausted T cells, of which PD-1 (tumor, R = 0.35, p = 3.4E − 12), CTLA4 (tumor, R = 0.35, p = 3.1E − 12), LAG3 (tumor, R = 0.34, p = 3.4E − 11), TIM-3 (tumor, R = 0.27, p = 1.1E − 07), and GZMB (tumor, R = 0.1, p = 0.048) in the tumor tissue dataset from TCGA were chosen (Table 1).