The findings of this investigation clearly asserted that (I) BDNF levels were lowered in Wet-AMD but not in Dry-AMD patients, (II) the CRP expression was elevated in Dry-AMD patients, (III) the CX3CR1 expression in Wet-AMD patients was demonstrably lower than Dry-AMD patients, and (IV) mainly CFH, CX3CR1, FLT1, and TIMP3 gene levels alongside HIF1A, IGFBP3, MAPK3, SOD1, STAT3, VGEFA, TIMP3, and SERPING1 gene levels were significantly reduced in both AMD types. Here, HIF1A is linked to age-related macular degeneration.