In univariable logistic regression, excluding age (P = 0.160), fibrinogen (P = 0.083), activated partial prothrombin time (APTT) (P = 0.064), and initial hematoma volume (IHV) (P = 0.088), other variables like NIHSS score (OR 1.12; 95% CI 1.02-1.23; P = 0.019), BHS (OR 3.47; 95% CI 1.24-9.74; P = 0.018), SS (OR 9.38; 95% CI 2.04-3.05; P = 0.004), IS (OR 23.08; 95% CI 6.81-78.20; P < 0.001), and presence of any NCCT sign (OR 6.44; 95% CI 2.36-17.59; P < 0.001) were associated with HE (Table 3). The gene discussed is F2; the disease is hereditary elliptocytosis.