The meta-analysis also indicated that the CTLA-4 gene rs3087243 polymorphism decreased RA risk [OR and 95% CI: 0.88 (0.85–0.92) in A vs. G; 0.83 (0.78–0.88) in AA+AG vs. GG; 0.88 (0.82–0.95) in AA vs. AG+GG; 0.79 (0.73–0.86) in AA vs. GG; and 0.84 (0.79–0.90) in AG vs. GG, Table 3]. The gene discussed is CTLA4; the disease is rheumatoid arthritis.