Pre-incubation of the HD76 neurons with the previously described (Wu et al., 2011) potential anti-HD drug and SOC inhibitor EVP4593 in concentration of 300 nM for 24 hours before lysis decreased expression level of huntingtin, returning it to the level comparable with control values (Figures 3A,B). The gene discussed is UBXN11; the disease is Huntington disease.