Indeed, in a previously described human neuroblastoma SK-N-SH HD model, we expected that overexpression of Hap1 protein (huntingtin associated protein 1) resulted in further SOCE increase, but we have not confirmed this effect since all SOC channels had already been activated upon mutant huntingtin expression (Czeredys et al., 2018). This evidence concerns the gene HAP1 and neuroblastoma.