Stabilization of podocytes on the GBM and glomeruli with increased capillary stiffness mediated by the calcineurin-WNK-OSR1/SPAK signaling pathway-stimulated increase in F-actin may contribute to protection of podocytes and glomeruli in some glomerular diseases and disease models where a component of glomerular injury is softening of glomeruli and podocytes (Wyss et al., 2011; Embry et al., 2016, 2018; Calizo et al., 2019; Ge et al., 2020). The gene discussed is OSR1; the disease is glomerular disorder.