Studies have shown that TRPC6 channel is expressed in microglia and involved in microglial activation and neuroinflammatory response in different diseases including hypertension, epilepsy, Alzheimer's disease, infectious diseases and neuropathic pain (Toth et al., 2013; Lee et al., 2014; Liu et al., 2017; Shinjyo et al., 2020; Wang et al., 2020b). Here, TRPC6 is linked to early-onset autosomal dominant Alzheimer disease.