Furthermore, a plethora of TS-miRNAs (including miR-7, miR-15b, miR-181b, miR-186, miR-320a, miRNA-323-5p, miR-383, miR-422a, miR-503, miR-505, and miR603) target IGF-IR messenger RNA in the non-neoplastic brain, thereby acting as tumor-suppressors. The gene discussed is IGF1R; the disease is neoplasm.