After CD30 CAR T-cell infusion, the splenomegaly continued shrinking(Figure 3D) to CR, and CT scans showed spleen and lung metastases (Figure 4A 2018.10.22), and lymphadenopathy in the neck, abdomen (Figure 4B 2018.10.22), and pelvis continued shrink to CR in four monthes. This evidence concerns the gene TNFRSF8 and Splenomegaly.