The results showed that the expression levels of E2F2, E2F3, E2F6, and E2F8 are significantly correlated with the tumor stage of PAAD patients, while the expression levels of E2F1, E2F4, E2F5 and E2F7 are not correlated with the tumor stage of PAAD patients. The gene discussed is E2F8; the disease is pancreatic adenocarcinoma.