E2F8 and pancreatic adenocarcinoma: In the Ishikawa (43) and Pei datasets (44), the expression levels of E2F7 and E2F8 in PAAD were significantly higher than normal tissues, with fold changes of E2F7 of 1.766 (P = 1.13E-4) and 2.029 (P = 2.31E-6), and fold changes of E2F8 of 2.063 (P = 0.007) and 3.028 (P = 2.67E-8), respectively.