MAPK10 and neoplasm: Furthermore, the experiments showed that promoter methylation was responsible for the mapk10 downregulation in HCC cell lines and tumor tissues, and the pharmacological demethylation and ectopic expression of mapk10 in silenced HCC cells could suppress the clonogenicity, induce the cell apoptosis, or enhance the sensitivity of HCC to 5-fluorouracil (5-FU).