As for 46 paired paraffin-embedded tissues, all of the adjacent non-tumor tissues show the positive expression of MAPK10, whereas 29 HCC tissues show the negative expression, the negative expression rate of MAPK10 between the HCC and the adjacent non-tumor tissues was significant (P < 0.0001) (Fig. 1). The gene discussed is MAPK10; the disease is hepatocellular carcinoma.