So far, the studies in HCC found some epigenetic silenced TSGs, such as p16, E-cadherin, hMLH1, SOCS1, SOCS, and RASSF1A, which play a role in proliferation, apoptosis, cell adhesion, invasion, and DNA repair (Tischoff & Tannapfe, 2008). This evidence concerns the gene CISH and hepatocellular carcinoma.