The target genes are involved in several signaling pathways including mTOR signaling pathway, PI3K-Akt signaling pathway, estrogen signaling pathway, hepatitis B, pathway in cancer and colorectal cancer, AMPK signaling pathway, FoxO signaling pathway as well as other signaling pathways that share target genes such as IKBKB, PIK3CA and AKT1 as shown in Table 2 (description of genes in Table S2). The gene discussed is PIK3CA; the disease is hepatitis B virus infection.