Interestingly, while a few of the 15 HUB genes had been evaluated elsewhere for their prognostic value in the context of lung adenocarcinoma (i.e., CDK1 (Shi et al., 2016), BIRC5 (Cho et al., 2015) and FOXM1 (Dai et al., 2015)), several of the HUB genes have only been sparsely covered. This evidence concerns the gene BIRC5 and lung adenocarcinoma.