SIRT1 and myocardial ischemia: For example, Niu et al. reported that lncRNA Oip5-as1 suppresses microRNA-29a, thus activating the SIRT1/AMPK/PGC1αpathway, which attenuates oxidative stress and mitochondria-mediated apoptosis during myocardial ischemia/reperfusion injury [42].