TNF and Hyperglycemia: Additionally, in rats, recent statement shows that painful neuropathy that results from STZ-induced type 1 diabetes is related to the release of proinflammatory cytokines such as IL-1β, IL-6, and TNF-α in serum and sciatic nerve [25] associated with allodynia and hyperalgesia [38] as a consequence of hyperglycemia and insulin resistance installation [26].