LEP and obesity due to melanocortin 4 receptor deficiency: During the development of obesity, adipocytes dysregulate adipokine production, which contributes to local and systemic inflammation and disturbances in glucose homeostasis [3], and these These adipokines include proinflammatory cytokines (e.g., leptin, tumor necrosis factor-α, and interleukin-6) and anti-inflammatory cytokines (e.g., adiponectin), all of which have multiple metabolic balance functions [3, 4].