At present, studies have found that the mechanism of vitamin D's effect on lipids mainly includes the following aspects: Li et al. [33] found that, in the state of vitamin D deficiency, VDR activity is significantly reduced, and it will lead to an increase in circulating cholesterol levels through Insig-2/SREBP-2/HMGR-dependent signaling pathways. Here, HMGA1 is linked to vitamin D deficiency.