HP and myocardial infarction: Suleiman et al. (2005) have reported that DM individuals with the Hp 2 allele have significantly larger myocardial infarctions than DM individuals homozygous for the 1 allele, which was confirmed in mice by Blum et al. (2007). The underlying mechanism of this relationship may be due to increased oxidative stress in DM Hp 2 mice (Blum et al., 2007).