ALOX5AP and chronic rhinosinusitis with nasal polyps: Previous studies on the genome-wide gene expression profile of CRSwNP showed increased ALOX5AP gene expression levels in the nasal polyps of patients with aspirin-intolerant asthma (Sekigawa et al., 2009) and decreased methylation levels of ALOX5AP in a genome-wide methylation profile of nasal polyps (Cheong et al., 2011).